The Second Department of Oncology (Department of Chemotherapy, Oncology) of the Second Hospital of Hebei Medical University is a comprehensive cancer-treatment department with chemotherapy as the main treatment method. The department has a team with high-quality doctors and professional nurses with rich experience in cancer diagnosis and treatment. There are two professors, one associate professor and one deputy chief physician, as well as one medical Doctor and five Masters in the department.

The scope of diagnosis and treatment of the SecondDepartment of Oncology includes: 1. chemotherapy for malignant tumor; 2. Molecular-targeted drug therapy for tumor; 3. tumor hyperthermia; 4. radiofrequency ablation treatment of solid tumor; 5. radiation tumor implantation of solid tumor; 6. Traditional Chinese Medicine treatment of malignant tumors; 7. Supportive treatment for patients with advanced cancer, treatment of cancer pain.

(i)Chemotherapy for malignant tumors

Chemotherapy of malignant tumors has been developed since the 1940s. It has a history ofmore than 60 years. At present, some malignant tumors can be cured by chemotherapy. For some tumors, the size and tumor growth rate have reduced and the condition has been improved and survival time has been prolonged after chemotherapy. In recent years, with the advent of molecular-targeted drugs, the level of anti-tumor drug treatment has been significantly improved, and the survival time of various tumor patients has been prolonged. Tumor chemotherapy is divided into the following categories:

1.Medical treatment of chemotherapy-sensitive malignant tumors:

At present, quite a considerable number of tumors can be long-term survival or cured through drug treatment, such as chorionic epithelial cancer, testicular seminoma, renal embryo sarcoma, neuroblastoma, acute lymphocytic leukemia, lymphoma, small cell lung cancer.

2. Adjuvant chemotherapy: Adjuvant chemotherapy refers to chemotherapy given to a malignant tumor after local effective treatment (surgery or radiotherapy). The purpose of adjuvant chemotherapy is to kill residual tumor cells in the body, reduce tumor recurrence and metastasis and prolong survival time. Adjuvant chemotherapy should be performed within 1 month after surgery and requires multiple courses of chemotherapy. A successful example of breast cancer, adjuvant chemotherapy and endocrine therapy can prolong survival time. Tumors for adjuvant chemotherapy include breast cancer, colorectal cancer, non-small cell lung cancer, ovarian cancer, and osteosarcoma.

3. Neoadjuvant chemotherapy refers to chemotherapy given to a localized tumor before surgery or before radiotherapy. The advantages are as follows: (1) Avoiding the latent metastases in the body to accelerate growth after the removal of the primary tumor due to the reduction of tumor burden in the body; (2) Tumor reduction is beneficial to the operation and obtaining the opportunity of resection; (3)Reducing the chance of metastasis due to surgery; (4)Demanding the sensitivity of the chemotherapy regimen and providing a reference for later chemotherapy. Tumors suitable for neoadjuvant chemotherapy include colorectal cancer, non-small cell lung cancer, breast cancer, ovarian cancer, and osteosarcoma.

4. Palliative chemotherapy in patients with advanced cancer

For patients with advanced tumors who are no longer suitable for localized treatment such as surgery or radiotherapy, chemotherapy is the main treatment. Clinical support with supportive therapies and biochemical regulators can improve the efficacy of chemotherapy drugs and improve the safety of the chemotherapy process. Such as advanced breast cancer, lung cancer, colorectal cancer, pancreatic cancer, kidney cancer, malignant melanoma, gastrointestinal stromal tumors.

5. Rescuing chemotherapy for malignant tumor emergency

When a chemotherapy-sensitive tumor causes an emergency, chemotherapy can be used to relieve symptoms and save the patient's life. To gain time for further treatment, such as spinal cord compression, superior vena cava compression, intracranial hypertension caused by brain metastases.

6. Special route of chemotherapy

According to the condition, chemotherapy can be carried out by different routes: intra-arterial infusion chemotherapy for solid tumors such as liver cancer and lung cancer; intrathoracic and intraperitoneal chemotherapy and hyperthermic perfusion chemotherapy;

(ii) Molecular targeted drug therapy

Targeted therapy is designed at the cellular level, targeting a well-defined tumor cell site (which can be a protein molecule inside a tumor cell, or a gene fragment) to design a therapeutic drug that enters the body. The combination of tumor cell sites is specifically selected to prevent tumor cell metabolism and cause tumor cells to die without affecting or less affecting normal tissue cells surrounding the tumor. Chemotherapy and targeted therapy can be compared toordinary bombs and precision-guided missiles. While ordinary bombs destroy targets, additional damage is also inevitable, but precision-guided missiles can accurately hit targets.

Tumor-targeted drug therapy needs to detect tumor cell targets, and each patient's tumor target performance is different, so it is necessary to choose individualized treatment. Targeted therapy has the advantages of accurately killing tumor cells, satisfactory curative effect and small side effects. A variety of targeted drugs targeting different targets have been used in clinical practice, benefiting many cancer patients. Such as rituximab (Mervastat) against CD20-positive lymphoma; trastuzumab (Herceptin) against HER2 gene-positive breast cancer and gastric cancer; Martinin (Gleevec)used to treat chronic myeloid leukemia and gastrointestinal stromal tumor; gefitinib (Iressa) and erlotinib (Troquet) for non-small cell lung cancer with epidermal growth factor receptor (EGFR) mutation, etc. The tumor-targeted drugs have achieved remarkable results.

(3) Tumor hyperthermia

Tumor hyperthermia refers to a type of treatment that uses heat to treat tumors. The basic principle is to use physical energy to heat the whole body or part of the human body, so that the temperature of the tumor tissue rises to the effective treatment temperature for a certain period of time and the difference in temperature tolerance between the normal tissue and the tumor cell can be utilized to achieve the apoptosis of the tumor cell, while it does not damage the normal tissue. Hyperthermia has become another important treatment after tumor surgery, radiotherapy, chemotherapy and immunotherapy. It is safe and effective, with good patient tolerance and small adverse reactions. It is known as tumor green therapy. Tumor hyperthermia has been widely carried out in the domesticand abroad.

It is divided clinically as follow:

1. Combined hyperthermia: ①combination of hyperthermia and chemotherapy, i.e. thermos-chemotherapy, can increase the concentration of drugs in the tumor and enhance the anti-tumor effect; at the same time, it can reduce the toxic effect of chemotherapy drugs on unheated normal tissues; It also helps prevent and delay the development of drug resistance. ②combination of hyperthermia and radiotherapy. It has confirmed clinically and experimentally that combination of radiotherapy and hyperthermia hasa great complementarity, heating can indeed enhance the killing effect of radiation on tumor cells.

2. Individual hyperthermia: For patients with advanced cancer who have relapsed after radiotherapy, chemotherapy or surgery, it is not appropriate to continue the above treatment. The palliative treatment can be performed by hyperthermia alone. In addition, to controlling the tumor, it can also relieve the intractable pain of advanced tumor and improve the patients' quality of Life.

A wide range of indications for tumor hyperthermia:

1. Respiratory system: pleural mesothelioma,lung cancer.

2. Digestive system: pancreatic cancer, gallbladder cancer, colorectal cancer, stomach cancer, liver cancer, esophageal cancer.

3. Reproductive system: ovarian cancer, cervical cancer, testicular cancer.

4. Urinary system: bladder cancer, kidney cancer.

5. Endocrine system: breast cancer, prostate cancer.

6.Blood system: malignant lymphoma, lymph node metastasis.

7. Advanced tumor intractable pain.

8. Cancerous pleural effusion, ascites.

Our department's tumor hyperthermia system is advanced in equipment and domestically leading. It can perform systemic and local hyperthermia at the same time. The curative effect is obvious, the cost is lower than the domestic equivalent treatment, and it is affirmed by patients and their families.

(4) Solid tumor radiofrequency ablation

Radiofrequency thermal ablation is a minimally invasive solid tumor in situ hyperthermia technique that has been developed in recent years. With the aid of imaging techniques such as ultrasound or CT, the electrode needle is directly inserted into the tumor. When radiofrequency current is generated by the electronic generator,, the electrode needle causes high-speed ion vibration and friction in the surrounding tissue, which is then converted into heat energy, which causes the lesion to locally generate high temperature, and finally the tumor tissue is coagulated and necrotic. Radiofrequency ablation is suitable for primary or metastatic solid tumors of liver cancer, kidney cancer, lung cancer, breast, bone and other parts. The curative effect is exact, the trauma is small, and the treatment of early solid tumors can achieve similar surgical resection and repeated treatment can be performed for recurrent and metastatic tumors that have lost the opportunity of surgery.

(5) Radioactive particle implantation for tumor treatment

Radioactive seed implantation is carried out by adsorbing radioactive isotope 125 iodine on a silver rod and encapsulating a titanium metal shell to form a titanium metal particle (called particle) having a diameter of 0.8 mm and a length of 4.5 mm.Implant it in the tumorand irradiate through a continuous low dose rate (valid for 8-12 months), which can effectively kill tumor cells continually. The therapy has the advantages of rapid, convenient, minimally invasive, high local dose and minimal surrounding tissue damage. It is currently one of the effective methods for the treatment of advanced tumors.

Indications: prostate cancer, lung cancer, head and neck cancer, pancreatic cancer, liver cancer, kidney and adrenal tumors, soft tissue tumors, etc.

(6) Traditional Chinese medicine treatment of tumor

The main aspect of TCM's understanding of cancer is different from modern medicine in the overall treatment, that is, dialectical treatment. Both clinical studies and experimental studies have confirmed that the overall treatment of traditional Chinese medicine has the functions of regulating the immune function of the patient, inhibiting the growth and metastasis of cancer cells and promoting the apoptosis of cancer cells. Traditional Chinese medicine treatment of tumors is an indispensable part of modern cancer treatment methods.

(7) Palliative treatment and standardized three-step analgesic treatment for advanced tumors:

The palliative treatment of tumors is a positive overall care for patients with cancer, including the control of pain and other symptoms. It focuses on solving patient psychology, sociology and spiritual problems. Palliative care not only shows the hospice care of patients with advanced cancer, but also the whole process of the disease according to the specific changes of the disease. Pain is a major component of palliative care. The WHO (World Health Organization) three-step pain treatment program is a widely accepted treatment for cancer pain medications around the world. As long as the basic principles are followed, most of the pain is well controlled.

Address of ward in general hospital of the Second Department of Oncology (Department of chemotherapy): 3rd inpatient building on the 1st floor (the first floor of the scientific research building); Address of the outpatient in general hospital: 4th floor of the outpatient building;

General Hospital Tel: 0311-66002338, 0311-66003818, 0311-66003817

The East Hospital has an outpatient clinic: Address: No. 80, Huanghe Avenue, East Development Zone, Shijiazhuang; Tel: 0311-66007349

March 2013